MicroRNA as a diagnostic marker in cutaneous T-cell lymphomas
نویسندگان
چکیده
BACKGROUND: In recent years, thanks to the development of methods molecular genetic analysis, microRNA has become one promising markers for diagnosis many human diseases.
 AIMS: study as a new method fungal mycosis.
 MATERIALS AND METHODS: The included 30 patients with histologically confirmed T-cell lymphomas skin, 25 were diagnosed mycosis, 5 ― Cesari syndrome. control group consisted 10 benign lymphoproliferative dermatoses. underwent determination 223, 16, 326, 663, 423, 711 in blood plasma. MicroRNA was also detected plasma skin at early and late stages.
 RESULTS: Statistically significant difference microRNAs revealed compared 663 stages. A statistically mycosis an stage dermatoses.
 CONCLUSION: can be used skin.
منابع مشابه
Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL).
Cutaneous T-cell lymphomas (CTCLs) are the most frequent primary skin lymphomas. Nevertheless, diagnosis of early disease has proven difficult because of a clinical and histologic resemblance to benign inflammatory skin diseases. To address whether microRNA (miRNA) profiling can discriminate CTCL from benign inflammation, we studied miRNA expression levels in 198 patients with CTCL, peripheral ...
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Primary cutaneous T-cell lymphomas (CTCLs) encompass a clinically and biologically heterogeneous group of non-Hodgkin lymphomas (NHLs) defined by clonal proliferation of skin-homing malignant T lymphocytes and natural killer cells. They account for up to 75% to 80% of all cutaneous lymphomas. The current WHO-EORTC classification of cutaneous lymphomas with primary cutaneous manifestations lists...
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1. Bardach H. Perforating lichen nitidus. J Cutan Pathol. 1981;8:111-6. 232-6. 2. Banse-Kupin L, Morales A, Kleinsmith DA. Perforating lichen nitidus. J Am Acad Dermatol. 1983;9:452-6. 3. Itami A, Ando I, Kukita A. Perforating lichen nitidus. Int J Dermatol. 1994;33:382-4. 4. Yoon TY, Kim JW, Kim MK. Two cases of perforating lichen nitidus. J Dermatol. 2006;33:278-80. 5. Rudd ME, Ha T, Schofiel...
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The gene encoding the beta-chain of the T-cell antigen receptor (TCR) has been analyzed for evidence of rearrangement in skin, blood, and lymph node specimens from 23 cases of known or suspected cutaneous T-cell lymphoma (CTCL). Two cutaneous large cell lymphomas, 4 cases of Sézary syndrome, and 5 cases of advanced (tumor) stages of mycosis fungoides showed clonal rearrangement of the TCR beta-...
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ژورنال
عنوان ژورنال: Rossiiskii Zhurnal Kozhnykh i Venericheskikh Boleznei
سال: 2022
ISSN: ['2412-9097', '1560-9588']
DOI: https://doi.org/10.17816/dv106327